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Use Plasmole in Claude and ChatGPT

Connect Plasmole's sequence tools to Claude or ChatGPT, then save results into your library.

The connector runs Plasmole's sequence tools inside Claude or ChatGPT. You need a free Plasmole account. It does not read your library. You save results yourself.

Connect Claude

  1. In Claude, open Settings > Connectors, click Add, then Add custom connector.
  2. Name it Plasmole and paste this URL: https://plasmo-backend.onrender.com/api/v1/mcp/mcp
  3. Leave Advanced settings blank and click Add.
  4. In a chat, turn Plasmole on from the + menu > Connectors.

On a Team or Enterprise plan, an Owner opens Organization settings > Connectors, clicks Add > Custom > Web, and pastes the URL. Members then click Connect in Settings > Connectors.

Connect ChatGPT

  1. Open chatgpt.com/plugins and search for Plasmole.
  2. Open the Plasmole plugin and click Try in chat.

The same plugin works in Codex. Business and Enterprise workspaces may need an admin to allow the plugin first.

Sign in and pick a workspace

Before the first tool runs, you sign in to Plasmole.

  1. Sign in with your Plasmole account.
  2. Pick the workspace the app may use. Personal is selected by default.
  3. Click Allow.

Workspaces with AI processing off cannot be picked.

Tools

Tool What it does
auto_annotate Annotates a sequence and draws its map
parse_plasmid_text Reads pasted GenBank, FASTA or .ape text
open_uploaded_plasmid_file Opens a plasmid file you upload
fetch_ncbi Fetches a sequence from NCBI by accession
search_ncbi Searches NCBI by gene or plasmid name
edit_sequence Inserts, deletes or replaces bases
assemble_fragments_by_overlap Joins fragments into a plasmid by their overlaps
export_plasmid_file Exports a plasmid as GenBank or FASTA
design_primers Designs PCR primers with Primer3
visualize_primers Shows primers on the map
calculate_tm Calculates melting temperature
find_restriction_sites Finds restriction enzyme sites
predict_digest Predicts digest fragments
design_guides Designs CRISPR guides
optimize_codons Optimizes codons for a host
check_design Scores a construct against design checks
align_two_sequences Compares two sequences and lists mutations
align_sequence_set Aligns several sequences
verify_clone_from_sanger_read Checks a clone against a Sanger read
list_construct_versions Lists a construct's versions
diff_construct_versions Compares two construct versions
restore_construct_version Restores an earlier construct version

Save a result to Plasmole

  1. Click Open in Plasmole → under a plasmid map, or Save to Plasmole → on a primer result.
  2. Pick a workspace and a project you lead. With no project there, name a new one.
  3. Click Save to Plasmole.

Disconnect

  1. In Plasmole, open Settings > AI Assistant > Connected apps.
  2. Click Disconnect next to the app. It loses access at once.

Something missing or wrong? Email [email protected].